张韬助理研究员
硕士生导师
联系邮箱：taozh@ziweiporn.com
个人简介
张韬，助理研究员，硕士生导师。博士毕业于德国杜塞尔多夫大学，福建省高层次人才（C类）。主持国家自然科学基金青年项目、福建省自然科学基金面上项目、福建省科技创新联合项目和自慰A片 高层次人才启动基金等多项课题，以第一或通讯（共同）作者在Translational Neurodegeneration, Pharmacological Research, Cell death & disease, CNS Neuroscience & Therapeutics, Molecular Neurobiology和ACS Chemical Neuroscience等杂志发表多篇学术论文，并担任Journal of Medicinal Chemistry，iScience和Molecular Neurobiology等杂志审稿人。
研究领域
1. 蛋白质异常折叠与聚集的发生机制和病理效应
2.神经退行性疾病的发病机制与干预
主持项目
1.国家自然科学基金青年项目，2021.01-2023.12，24万元，主持，已结题
2.福建省科技创新联合资金项目，2024.01-2026.12，15万元，主持，在研
3.福建省自然科学基金面上项目，2021.11-2024.11，7万元，主持，已结题
4.自慰A片 高层次人才启动基金，2020.03-2025.03，20万元，主持，已结题
5.福建省科技创新联合资金项目，2025.01-2027.12，100万元，参与，在研
科研成果(*, 共同一作；#，共同通讯)
1. Mei Y, She F, Zhang L, Kim G, Li R, Zheng X, Wang Z, Chen R, Wang L, Chen D, Kim J, Zhang T#, Lee TH#. Zipper-interacting protein kinase mediates neuronal cell death and cognitive dysfunction in traumatic brain injury via regulating DEDD. Cell Death Dis. 2025 Mar 4;16(1):151. (#Co-corresponding author)
2. Chen D, Li R, She F, Chen J, Cho SM, Yang B, Tian Y, Guan L, Zheng X, Wang Q, Wang L, Park SW, Tao W, Zhang T#, Kim BM#, Lee TH#. Saikosaponin C ameliorates tau-related pathology by modulating oxidative stress and MAPK axis in Alzheimer's disease. J Ethnopharmacol. 2025 Jun 28:352:120221. (#Co-corresponding author)
3. She F, Zhang T#, Lee TH#. Multifaceted role of zipper-interacting protein kinase beyond cell death: Implication of ZIPK dysregulation in neuronal and vascular injuries. Pharmacological Research. 2025 May 21; 107793. (#Co-corresponding author)
4. Zhang T, Kim BM, Lee TH. Death-associated protein kinase 1 as a therapeutic target for Alzheimer's disease. Transl Neurodegener. 2024 Jan 9;13(1):4.
5. Tian Y, Zheng X, Li R, Hu L, Shui X, Wang L, Chen D, Lee TH#, Zhang T#. Quantitative Proteomic and Phosphoproteomic Analyses Reveal a Role of Death-Associated Protein Kinase 1 in Regulating Hippocampal Synapse. Mol Neurobiol. 2024 Mar;61(3):1794-1806. (#Co-corresponding author)
6. Zhang T*, Tian Y*, Zheng X, Li R, Hu L, Shui X, Mei Y, Wang Q, Zhang M, Zheng X, Wang L, Chen D, Tao W, Lee TH. Activation of transient receptor potential vanilloid 1 ameliorates tau accumulation-induced synaptic damage and cognitive dysfunction via autophagy enhancement. CNS Neurosci Ther. 2024 Mar;30(3): e14432. (*Co-first author)
7. Chen D, Chen Q, Qin X, Tong P, Peng L, Zhang T#, Xia C#. Development and evolution of human glutaminyl cyclase inhibitors (QCIs): an alternative promising approach for disease-modifying treatment of Alzheimer's disease. Front Aging Neurosci. 2023 Aug 3;15: 1209863. (#Co-corresponding author)
8. Zhang T*, Xia Y*, Hu L, Chen D, Gan CL, Wang L, Mei Y, Lan G, Shui X, Tian Y, Li R, Zhang M, Lee TH. Death-associated protein kinase 1 mediates Aβ42 aggregation-induced neuronal apoptosis and tau dysregulation in Alzheimer's disease. Int J Biol Sci. 2022 Jan 1;18(2):693-706. (*Co-first author)
9. Gan CL*, Zhang T*, Lee TH. The Genetics of Alzheimer's Disease in the Chinese Population. Int J Mol Sci. 2020 Mar 30;21(7):2381. (*Co-first author)
10. Zhang T, Zhao L, Zhan R, Yuan GH, Han HB, Cui DH. Novel Mechanisms of some Traditional Chinese Medicine for the Therapy of Neurocognitive Disorders. Progress in Biochemistry and Biophysics. 2020 47(8):729-742
11. Zhang T, Chen D, Lee TH. Phosphorylation Signaling in APP Processing in Alzheimer's Disease. Int J Mol Sci. 2019 Dec 27;21(1):209.
12. Zhang T, Gering I, Kutzsche J, Nagel-Steger L, Willbold D. Towards the mode of action of the clinical stage all-D-enantiomeric peptide RD2 on Aβ42 aggregation. ACS Chem Neurosci. 2019 Dec 18;10(12):4800-4809.
13. Zhang T, Loschwitz J, Strodel B, Nagel-Steger L, Willbold D. Interference with amyloid-β nucleation by transient ligand interaction. Molecules. 2019 Jun 5; 24(11). pii: E2129. (Cover story)
14. Zhang T, Nagel-Steger L, Willbold D. Solution-based determination of dissociation constants for the Binding of Aβ42 to antibodies. ChemistryOpen. 2019, 8, 989-994.
15. Zhang T, Pauly T, Nagel-Steger L. Stoichiometric Zn2+ interferes with the self-association of Aβ42: insights from size distribution analysis. Int J Biol Macromol. 2018 Feb 22; 113:631-639.
16. Wang HC*, Zhang T*, Kuerban B, Jin YL, Le W, Hara H, Fan DS, Wang YJ, Tabira T, Chui DH. Autophagy is involved in oral rAAV/Aβ vaccine-induced Aβ clearance in APP/PS1 transgenic mice. Neurosci Bull. 2015 Aug; 31(4):491-504. (*Co-first author)
17. Zhang T, Tian X, Wang Q, Tong Y, Wang H, Li Z, Li L, Zhou T, Zhan R, Zhao L, Sun Y, Fan D, Lu L, Zhang J, Jin Y, Xiao W, Guo X, Chui D. Surgical stress induced depressive and anxiety like behavior are improved by dapsone via modulating NADPH oxidase level. Neurosci Lett. 2015 Jan 12; 585:103-8.
（更新至2025年7月）
